Tuesday, August 27, 2013

Earth Waves To Saturn


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Image of the Week #106, August 26th, 2013:

From: Earth Waves To Saturn: The Pictures by Caleb A. Scharf at Life, Unbounded.

Source: NASA/JPL-Caltech

NASA as an organization is positioned to deliver some of the greatest and most inspiring images in human history and they don?t shirk from that duty. Ever since the earthrise from the moon, or since Carl Sagan exhorted the importance of getting that Pale Blue Dot picture taken, NASA has looked for ways to include all of us in space.

In Caleb Scharf?s post Earth Waves To Saturn: The PicturesEarth Waves to Saturn: The Pictures, NASA has not only done it again, they?ve included all of us in the most contemporary crowd-sourced way possible. The result is once again a reflection of our collective potential.

Bora Zivkovic About the Author: Bora Zivkovic is the Blog Editor at Scientific American, chronobiologist, biology teacher, organizer of ScienceOnline conferences and editor of Open Laboratory anthologies of best science writing on the Web. Follow on Twitter @boraz.

The views expressed are those of the author and are not necessarily those of Scientific American.

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Thursday, August 22, 2013

New skylight scoops up daylight, save energy

[unable to retrieve full-text content]Light scoops provide optimal levels of daylight throughout the changing seasons and daily fluctuations in weather by capturing and strategically redirecting daylight into buildings.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/RRX5etNxnwQ/130820185347.htm

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Wednesday, August 21, 2013

Sierra Leone says arrests soldiers planning presidential protest

FREETOWN (Reuters) - Sierra Leone's army said it arrested nine soldiers over the weekend for planning a protest during a visit by President Ernest Bai Koroma to his hometown.

The arrests highlight increasing disgruntlement with Koroma among the Sierra Leone army, who have complained of low wages and inadequate housing as the country struggles to emerge from the 1991-2002 civil war.

A source from the defense ministry, who asked not to be named, said the soldiers had actually intended to kidnap the president and murder the defense minister during the visit, which was later canceled - though that account could not be verified independently.

"We ... had suspicions of a protest against the president. We had heard about a suspicious meeting of junior officers and decided to make the arrest," army spokesman Michael Samura told Reuters.

He declined to comment on the report from the defense ministry source and did not say what the soldiers were planning to protest about.

Presidential spokesman Jarrah Kawusu-Konte said Koroma decided to cancel his weekend trip to Makeni, about 140 km (86 miles) north of the capital Freetown, at the last minute, but would not confirm if it was because of a security threat.

"The president is safe and this is no cause for alarm," Kawusu-Konte said.

Koroma won a second term in a presidential election last year, the country's third election since the end of the 11-year civil war that made it notorious for child soldiers and "blood diamonds" used by rebels to fund the conflict.

(Reporting by Christo Johnson and Nina de Vries; Writing by Bate Felix; Editing by Andrew Heavens)

Source: http://news.yahoo.com/sierra-leone-says-arrests-soldiers-planning-presidential-protest-181111895.html

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Tuesday, August 20, 2013

Concerned Israel quietly backs Egypt's military

By Jeffrey Heller

JERUSALEM, Aug 19 (Reuters) - Israel is urging the West to stick by Egypt's army in its confrontation with the Muslim Brotherhood, quietly echoing warnings by U.S. regional ally Saudi Arabia against putting pressure on the military-backed government.

"Israel shares its views with the U.S. and some EU (European Union) countries, and those views are to give priority to restoring stability," a senior Israeli official said on Monday.

"And like it or not, the army is the only player that can restore law and order (in Egypt)."

With Prime Minister Benjamin Netanyahu's cabinet instructed by him to avoid public comment about turmoil in Egypt, where about 850 people, including 70 police and soldiers, have been killed in nearly a week of violence, government officials have been speaking, anonymously, about Israel's concerns.

Among them is any sign of weakened support for an Egyptian military that maintained close security ties with Israel even during the year-long rule of President Mohamed Mursi, the Muslim Brotherhood leader deposed by the army on July 3 after huge protests against him.

Responding to the mounting death toll on Egypt, the United States has postponed delivery of four F-16 fighters and scrapped a joint military exercise with the Egyptian armed forces, but has not withheld $1.55 billion in annual aid.

That decision, one Israeli official said, "raised eyebrows" in Israel, which signed a peace treaty with Egypt in 1979 that has been underpinned by a working relationship between the armed forces of both countries.

But other officials insisted there was no formal Israeli lobbying drive in Washington to dissuade President Barack Obama from taking any stronger measures to try to curb the Egyptian military crackdown.

"When we speak (to U.S. officials), we clearly say what we think. It doesn't mean there is a campaign. We share our views and analysis," one official said.

"With what other neighbour of Egypt can they speak about this? We are the only nation they can speak to what's right on the border; obviously there's a lot to exchange."

Israel, hoping to preserve its peace treaty with Egypt, was muted in its response to Mursi's election as president a year ago after autocrat Hosni Mubarak's ouster, Netanyahu was vocal in the past about his fears of an Islamist takeover in Egypt.

Such a scenario, he said in 2011, represented a "tremendous threat" to Egyptian-Israeli cooperation.

Elsewhere in the region, Saudi Arabia has publicly cautioned the West against measures aimed at reining in the military in its efforts to curb the Muslim Brotherhood.

"We will not achieve anything through threats," Prince Saud al-Faisal, the Saudi foreign minister, told reporters in Paris on Sunday ahead of an EU foreign ministers' meeting in Brussels to review the 28-nation bloc's Egyptian policy.

Israel sees Egypt's armed forces as critical in confronting Islamist fundamentalism on a national level and dealing with attacks by Islamist militants in the Sinai Peninsula, which has a long desert border with the Jewish state.


SINAI ATTACKS

Deepening Israel's worries about increasing lawlessness on its doorstep, suspected Islamist gunmen killed at least 24 Egyptian policemen in an ambush in Sinai on Monday.

Just last week, Israel's Red Sea resort of Eilat, on the border with Sinai, was targeted by a rocket apparently fired by Islamist militants. It was shot down by an Israeli missile shield.

Tzachi Hanegbi, a legislator from Netanyahu's right-wing Likud party and a confidant of the prime minister, said it was also in Washington's strategic interest to maintain good relations with Egypt's leaders.

"Every year, Egypt gets 1.5 billion dollars, mainly in military aid. The U.S. military ... gets preferential treatment for passage in the Suez Canal and in Egyptian air space. All these things have greatly assisted the United States in its operations in the Middle East," he told Army Radio on Sunday.

Hanegbi, a member of parliament's Foreign Affairs and Defence Committee, said that while Washington needed to voice its displeasure over bloodshed in Egypt, "the paramount U.S. interest is not to take steps from which there is no way back".

(Additional reporting by Dan Williams and Allyn Fisher-Ilan, editing by Mark Heinrich)

? 2011 Reuters

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Source: http://feeds.vision.org/~r/NewsFromReuters/~3/7TxFISiVkEY/article.aspx

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Sunday, July 7, 2013

Obama says U.S. is not aligned with any Egyptian party: White House

By Steve Holland

WASHINGTON (Reuters) - President Barack Obama condemned the violence in Egypt on Saturday and said that the United States was not working with any particular Egyptian political party or group as the country reels from a military takeover.

Obama, spending the weekend at the Camp David presidential retreat, convened a secure conference call with members of his national security team to discuss events in Egypt days after a military ouster of elected President Mohamed Mursi and his Muslim Brotherhood-led government.

"The president condemned the ongoing violence across Egypt and expressed concern over the continued political polarization. He reiterated that the United States is not aligned with, and does not support, any particular Egyptian political party or group," a White House statement said.

The Obama administration had grown skeptical of Mursi's ability to lead Egypt. While the United States has expressed concern about the military takeover, it has not condemned it nor called it a coup, prompting speculation that the United States tacitly supports it.

Obama has ordered a review to determine whether annual U.S. assistance of $1.5 billion, most which goes to the Egyptian military, should be cut off as required by law if a country's military ousts a democratically elected leader.

Violence sweeping Egypt in reaction to Mursi's ouster has led to the deaths of 35 people.

The White House statement did not comment on way or the other on the fact that liberal Egyptian politician Mohamed ElBaradei, a former U.N. nuclear agency chief, had been appointed as interim prime minister to lead Egypt's transitional government.

"The United States categorically rejects the false claims propagated by some in Egypt that we are working with specific political parties or movements to dictate how Egypt's transition should proceed," the statement said.

Washington is urging Egypt's military to move quickly back toward a "sustainable democracy." The White House statement urged all Egyptian leaders to come together in an inclusive process that allows the participation of all groups and political parties.

"We urge all Egyptian leaders to condemn the use of force and to prevent further violence among their supporters, just as we urge all those demonstrating to do so peacefully. As Egyptians look forward, we call on all sides to bridge Egypt's divisions, reject reprisals, and join together to restore stability and Egypt's democracy," it said.

(Reporting By Steve Holland; Editing by Sandra Maler and Eric Walsh)

Source: http://news.yahoo.com/u-not-aligned-egyptian-party-white-house-210924792.html

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Tiny Chinese enclave remakes gambling world, Vegas

LAS VEGAS (AP) -- Most people still think of the U.S. gambling industry as anchored in Las Vegas. They might think of vestiges of the mob, or the town's ill-advised flirtation with family-friendly branding in the 1990s.

But they would be wrong.

The center of the gambling world has shifted 16 time zones away to a tiny spit of land on the southern tip of East Asia.

An hour's ferry ride from Hong Kong and an afternoon flight from half the world's population, Macau is the only place in China where casino gambling is legal.

Each month, 2.5 million tourists flood the glitzy boomtown to try their luck in neon-drenched casinos that collect more winnings than the entire U.S. gambling industry. The exploding ranks of the Chinese nouveau riche sip tea and speak in hushed tones as they play at baccarat, a fast-moving game where gamblers are dealt two cards and predict whether they will beat the banker.

The textile factories that stood shoulder to shoulder with small-time gambling halls as recently as the early 2000s have given way to hulking American-run enterprises larger than anything found in the states. The gangs, prostitutes and money-launderers that once operated openly in this town half the size of Manhattan have at least receded from public eye.

"It was a swamp," said Sheldon Adelson, CEO of Las Vegas Sands, as he looked back on his early, risky venture in the forgotten colonial outpost.

"They wanted to change the face of Macau from the gambling dens to that of conventions and resorts," he added during recent testimony, flashing a jack-o-lantern grin and boasting that it would have taken a genius to imagine the profits that he could reap there.

Macau now powers three of the four largest American casino companies. Sands, Wynn Resorts Ltd and MGM Resorts International rode out the recession thanks to the gambling appetite of a region where notions of luck and fate are baked into the culture, and there is no religious taboo on games of chance.

But as U.S. corporations have remade Macau, Macau has remade them.

The town's criminal undercurrent has resurrected the specter of corruption the industry worked for so long to escape. MGM has lost its license to operate in Atlantic City, while Sands and Wynn are under federal investigation for violations of a touchstone anti-corporate bribery law.

The quest for Asian riches is changing Las Vegas as well. Casino bosses are tweaking their flagship casinos to look and operate more like Macau-style properties. As they succeed, hints of organized crime are returning to Sin City, this time in the form of Chinese gangs.

But the moguls are undeterred, increasing their investment at every opportunity.

"This industry is supply driven, like the movie Field of Dreams: 'Built it and they will come.' I believe that,'" Adelson, racing ahead of his attorney on the witness stand in Las Vegas, where he is being investigated for bribing Macau lawmakers and collaborating with the Chinese mafia. "Nobody wanted it. Everybody thought that I was crazy."

At 80 and greatly enriched now by his growing field of five Macau casinos, the diminutive GOP super donor adopted a professorial tone and explained that in 2003, Macau officials gave him a plot of land far from what passed at the time for a main drag. They encouraged him to fill in the surrounding bay.

"I thought, 'Do they want us to fail?'" Adelson asked, patting the ring of brown hair arranged across his round head.

When China reassumed sovereignty of Macau from Portugal in 1999 and abolished a longstanding gambling monopoly, U.S. companies rushed in to try their luck. Since then, annual revenue in the former backwater has grown tenfold, stacking up to $38 billion; four times that of Las Vegas and Atlantic City combined.

Wynn Las Vegas now makes nearly three quarters of its profits in Macau. CEO Steve Wynn, dubbed the "King of Las Vegas" for his role in shaping the contours of the Strip, stirred a minor scandal in 2010 when he said he might ditch Sin City and move his corporate headquarters to China.

Sands, which owns the Venetian and Palazzo on the Las Vegas Strip, earns two thirds of its revenue in Macau. Adelson's first casino opening there caused a stampede that ripped doors off their hinges. He now describes Sands as "an Asian company with a presence in Las Vegas and the U.S."

When regulatory troubles forced MGM Resorts to pick between Macau and New Jersey, the choice was obvious.

"The Macau market is now larger than the entire U.S. gaming market. Unfortunately for Atlantic City, it's gone the other way. It's smaller now than when we entered it. The fortunes of the two couldn't be more different," MGM CEO Jim Murren said.

Macau is in the midst of one of the greatest gambling booms the world has ever known. To rival it, Las Vegas would have to attract six times as many visitors; essentially every man, woman and child in America.

But like early Las Vegas, Macau has a long history of ties to crime syndicates, in this case sinister brotherhoods that first came into being on the mainland more than a century ago called triads. The magnate who controlled gambling in Macau for four decades, Stanly Ho, did little to discourage gang warfare on the peninsula.

Sleepy town squares became incongruous backdrops for machine-gun shoot-outs, bombings and even assassinations of top-level government officials. In the late 1990s, a senior police official tried to reassure tourists by saying that Macau had "professional killers who don't miss their targets."

The history and regulations governing the enclave continue to make it tricky for modern casinos to avoid gangs, illegal money transfers, and at least the appearance of bribery.

"There are some countries where you either have to pay to play and break the law, or you have to not do business there. I think the jury's still out on Macau," said Steve Norton, an Atlantic City veteran who now runs a casino consulting firm in Indiana.

Adelson himself seemed to confirm this point on the stand this spring, when he casually mentioned that Sands had forgone a partnership with a successful Hong Kong-based casino operator because of a disagreement about organized crime.

"They had expressed their judgment that they were going to do business with either reputed, or-- triad people, and we couldn't do that," Adelson said, sipping from an oversized coffee cup.

Local policies are partly to blame. China bans its citizens from transferring more than $50,000 off the mainland each year; a pittance at many high roller tables, and nowhere near enough to account for the towers of chips that change hands in Macau. It also bans casinos from pursuing gambling debts.

Partly as a result, a thriving junket system has sprung up, with supercharged travel agents whisking VIPs to the gambling tables, lending them money, and then settling up on the mainland.

Junket operators sometimes work on commission, but more often assume management of a private VIP room. Casinos provide the gleaming marble facilities, dealers, and chips in return for a cut of the profits. Two-thirds of Macau gambling revenue is won from baccarat played in VIP rooms.

The informal banking and debt collection system provides a veil and an impetus for criminal activity, according to experts and diplomatic cables.

Junkets "allegedly work closely with organized crime groups in mainland China to identify customers and collect debts" and "work directly with Macau casinos to buy gaming chips at discounted rates, allowing players to avoid identification," according to a memo posted by Wikileaks.

The memo, which was apparently sent from the American Consulate in Hong Kong in 2009, continues, "Government efforts to regulate junket operators in Macau have been aimed at limiting competition, rather than combating illicit activities."

Operating off the books, junkets pay out winnings in Hong Kong dollars, which players can then funnel to another location. As a result, Macau is seen as a conduit for money flowing out of China, with wealthy individuals and corrupt officials suspected of moving funds abroad. At least 15 government officials have been executed for pillaging public funds and taking the money to Macau.

The enclave has also seen a spate of killings and kidnappings associated with debt collection, including one grizzly case last year in which two men were stabbed to death in their four-star hotel room, discovered by a friend who had come to give lend them the money they needed.

And while many of the approximately 200 junkets active in Macau are law-abiding, some have documented ties to organized crime.

The case of Cheung Chi-tai, a major investor in the publically traded junket operator Neptune Group, is a prime example.

In 2011, a Hong Kong appeals court judgment said Cheung was a "triad leader" who ordered the death of a casino dealer at Sands Macau. He had previously been identified as high-ranking gang figure in a 1992 U.S. Senate report on Asian organized crime.

A witness testified that Cheung was "the person in charge" of one of the VIP rooms at the Sands Macau, the oldest of the Adelson's Macau casinos.

He wasn't charged in the case, but a subordinate was sentenced for conspiracy to commit murder.

"There's no way you can do business over there without having allegations made against you, most of them are untrue," said Bill Weidner, who was president of Sands until 2008.

Casino bosses are now working to lure their Macau customers to Las Vegas, in part because Nevada imposes one fifth of China's 39 percent tax on winnings. The biggest casinos on the Strip have imported baccarat, now Nevada's biggest moneymaker, Asian pop sensations and Chinese delicacies. They've outfitting their hallways in red, and set up Macau-style VIP rooms that employ junkets and cater to high rollers.

"The Las Vegas casinos are adopting that new Macau look, trying to appeal to the high-end Asian gambler. They can make a lot more money from a big gambler here," said David Schwarz, director of the Center for Gaming Research at the University of Nevada Las Vegas.

Asian visitors now account for 9 percent of tourists to the desert metropolis, up from 2 percent in 2008. And the Strip is preparing to welcome its first Asian-owned casino; a $5 billion Chinese-themed extravaganza called Resorts World, complete with pandas and pagodas.

But some of the crime associated with Chinese gambling halls may be migrating to the Strip as well.

Last year, the Treasury's Financial Crimes Enforcement Network warned casinos to monitor junkets operators and report "all available information" on any suspicious activity.

Sands reportedly allowed a junket operator named as a triad member in the 1992 Congressional report to move a $100,000 gambling credit from Las Vegas to one of its Macau casinos.

Las Vegas is also beginning to see occasional outbursts of triad violence.

In March, 26 year-old Xiao Ye Bai began serving a life term for stabbing a man to death in a crowded karaoke bar near the Strip. Prosecutors said Bai was a martial-arts trained enforcer for the Taiwan-based triad United Bamboo, sent to collect a $10,000 gambling debt.

Unlike some other states, Las Vegas allows junket operators to work in casinos without the full background checks required for virtually every other employee, from blackjack dealers to CEOs.

Some of Hong Kong operators licensed in Nevada have been found unsuitable by other jurisdictions, including Singapore.

Steve Vickers, who spent 18 years in the Royal Hong Kong Police Force and commanded the its criminal intelligence bureau, believes that nearly all junkets that cater to Chinese tourists must tangle with organized crime.

"You won't find the triad names listed as the junket operators, but they are behind it, because who is it that can reach into China and enforce the debts, move the money? Only one kind of person can do that," he said.

Authorities in Nevada, New Jersey and Washington DC are investigating all three of the U.S. companies with properties in Macau.

? New Jersey regulators objected when MGM teamed up with Stanley Ho's daughter, Pansy, because of the senior Ho's triad links. The state found the partnership "unsuitable" in a blistering 2010 report, and forced MGM to sell its stake in the Borgata casino in Atlantic City. MGM and the family of Pansy Ho deny the allegations.

Nevada, where casino revenue provides about half of the state's general fund, examined the MGM partnership and found it acceptable. Mississippi and Michigan also approved. This year, New Jersey allowed MGM to re-apply for a license.

? Wynn is under investigation for donating $135 million to the University of Macau in 2011. A former board member says the payment was a bribe and a violation of the Foreign Corrupt Practice Act. In a footnote in a March legal filing, U.S. prosecutors revealed they were looking into the donation, but did not elaborate.

Established in 1977 as part of a series of reforms intended to restore the nation's standing after the Watergate scandal, the Foreign Corrupt Practice Act bars U.S. companies from paying off officials to win business, though it makes an exception for small administrative payments that do not confer unfair advantage.

The Department of Justice has recently stepped up its enforcement of the act. As the business world becomes more globalized and other countries adopt similar laws, U.S. companies can no longer argue that enforcing the ban gives an edge to rivals.

In recent years, the act has been used to take on the pharmaceutical company Pfizer (for payments to foreign doctors), Rupert Murdoch's News Corp. (for paying British police officers for information) and Wal-Mart (for an ongoing Mexican bribery scandal).

The law was most famously deployed in the "bananagate" scandal, in which a U.S. fruit company was charged with bribing the Honduran president for favorable tax rates. The uproar ultimately precipitated a government overthrow.

But Macau regulators draw fewer bright lines around corporate gift-giving than their American counterparts, according to I. Nelson Rose, a professor at Whittier Law School in California who writes a blog called Gambling and the Law. What might look like a bribe on American soil is a routine part of the culture in Macau, he said.

Wynn says it acted properly. Nevada regulators looked into the donation before the federal investigation was made public and found no wrongdoing.

?A long list of agencies, including the Department of Justice, the Securities and Exchange Commission and the FBI, are investigating Sands. Those inquiries stem from a 2010 lawsuit brought by former Sands executive Steve Jacobs. In an ongoing wrongful termination suit, Jacobs says Sands' China subsidiary allowed triad boss to run one of the company's VIP rooms, tacitly condoned prostitution, and made inappropriate payments to a Macau lawmaker, among other "outrageous" misdeeds.

Sands has denied all claims, but recently said in a Securities and Exchange Commission filing that an internal audit had found possible breaches of the Foreign Corrupt Practice Act.

The law contains two parts: it prohibits bribing a foreign official to win patronage and it requires that public companies file proper financial statements and maintain a system of internal controls. Sands admitted to likely violations of the second, more bureaucratic, provision.

"There were likely violations of the books and records and internal controls provisions of the FCPA," the company said in an annual report filed in March.

In April, the auditor for Sands' China subsidiary resigned.

Both Sands and Wynn are facing related lawsuits from individual shareholders who claim mismanagement has damaged the company.

It sounds bad. But is it?

Probably not, according to Fitch ratings analyst Michael Paladino. At worst, the companies could get fined.

"They can handle that," he said.

He noted that the largest fine paid in modern corporate history? imposed on German engineering giant Siemans A.G. for bribery? amounted to about $1 billion. That's equivalent to one month's profits for Sands.

Justice Department spokesman Michael Passman declined to comment.

Wall Street seems to share Paladino's confidence. Not one analyst or investor raised the issue of corruption charges during recent conference calls held by the three companies to discuss earnings.

"For the average person going to a casino, they're not going to stop going because the company that owns the facility is implicated in some kind of corruption scandal," said Peggy Holloway, vice president and senior credit officer at Moody's.

States also have the power to impose fines, and can revoke licenses.

Nevada regulations prohibit casino companies from doing anything anywhere in the world that could "reflect discredit upon the State of Nevada or the gaming industry."

Similar statutes exist in New Jersey, Pennsylvania, Mississippi, Michigan, Illinois and Connecticut, where the companies with properties in Macau operate.

In the 1980s, these rules helped push out the mob bosses that had taken refuge in the casino industry and usher in its modern corporate era, though the FBI and other federal agencies did the heavy lifting.

A Congressional report issued in 1999 found that American gambling was finally free from the taint of organized crime.

That was the same year China opened Macau to U.S. investment.

State regulators have so far refrained from public action, preferring to stay out of federal investigations until a conclusion is reached, Nevada Gaming Board Chairman AG Burnett said. But that does not mean they are sitting idle.

"I think there's an impression out there that the control board doesn't hammer companies, but the truth is that a lot of what goes on is dialogue between the board and the companies that the public doesn't necessarily see," he said.

While the regulators occasionally file complaints for egregious violations? for instance, the Palms hotel-casino paid a $1 million fine this winter for abetting prostitution and drug dealing ? they prefer to handle things quietly, partly of concern for the industry they police.

"When you're dealing with a publicly traded company, the sheer fact of an investigation being made public may be damaging. And if at the end of the day if we find that there's no violation, then unfortunately, we may have harmed the company," Burnett said. "It increases our ability to work with the companies more fluidly and have more of a dialogue. While we work against the industry sometimes, it's helpful if we can work with them."

Conventional wisdom is that no casinos will lose their licenses over the Macau allegations, even if they prove true.

And in any case, Sands, Wynn and MGM have already put their China operations into subsidiaries which could eventually be spun off entirely.

"If I were one of these operators, I might start tallying up how much my U.S. operations are worth and how much my Macau operations are worth and thinking about moving," said Vickers, the former intelligence officer, who now consults about risk management in Hong Kong.

The balance of power between casinos and regulators has shifted as gambling companies have achieved their own version of outsourcing, according to Rose, the professor.

"Macau forced the casinos to see that they could become like other large U.S. corporations; set up their plants and operations in other nations and make far more than they can being stuck just in Las Vegas," he said, speaking from his hotel room near Macau University, where he teaches a summer course.

It helps that public officials aren't exactly clamoring for justice.

Among the ranks of the unconcerned is former Las Vegas mayor Oscar Goodman, who famously demanded an apology from Barack Obama after the president cautioned against blowing "a bunch of cash in Vegas when you're trying to save for college."

Sitting in the living room of his five-bedroom home among dozens of bobble head dolls cast in his image, Goodman, whose wife is now mayor, said he doesn't worry about Macau because Americans are not paying attention to the murky allegations there.

"If it brought discredit to us, of course I would become concerned, defensive, and try to rectify the station. But the average person could care less about this," he said, straightening his pinstripe suit, an affectation left over from his days as a nationally-famous mob lawyer.

"You ask people who Sheldon Adelson is, if 10 out of 50 recognize the name, I'd be surprised. If they associated him with the Venetian and the Palazzo, I'd be even more surprised. People are busy."

Of course, within the industry, Adelson is an object of fascination. As the casino titan sat in a courtroom among a phalanx of employees, security and family members this spring, a former rival was following along from his home 500 miles to the north in Reno, Nevada's second, shabbier gambling town.

While Wynn, MGM and Sands have taken off, the industry's' fourth major player, Caesars Entertainment International, has been left behind.

China issued a finite number gambling licenses in the early 2000s, and Caesars did not apply for fear of upsetting domestic regulators. The company's former head now calls that an overcautious mistake.

Phil Satre, who was CEO in 2003, when Caesars was called Harrah's Entertainment, said that at the time, the gambling industry had at last gained a legitimacy and mundane familiarity that was unthinkable in the 1980s. Many executives thought American regulators wouldn't countenance any dalliances with criminal elements in Asia.

"There are some things that still have to play out, but when I look back and think about the opportunity to go back in Macau, I'd probably take a different posture," he said.

___

Hannah Dreier can be reached at http://twitter.com/hannahdreier .

Source: http://news.yahoo.com/tiny-chinese-enclave-remakes-gambling-135832208.html

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Corning Watch: Corning Inc. sees new future in windows

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Source: http://www.stargazette.com/article/20130706/BUSINESS/307060010/1113/

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Crash landing at San Francisco mirrors that of Boeing 777 crash at London Heathrow five years ago

  • Crash has parallels to that of British Airways 777 crash in 2008
  • 777 plane came down short of the runway at London Heathrow similar to San Francisco
  • In both crashes, the wings and fuselage remained intact with the aircraft crashing well before the runway 'touchdown zone'

By James Daniel

|

Today's crash of an Asiana Airline Boeing 777 at San Francisco Airport has striking similarities with the crash of a British Airways 777 five-and-a-half years ago.

In both instances, the aircraft came down before the threshold of the runway after coming to the end of a long haul flight.

The hull of both planes also remained largely intact with the majority of the passengers walking away unhurt, shaken with just a few cuts and bruises.

Crash no.1: The crash of a British Airways Boeing 777 on landing in London Heathrow was caused by ice crystals forming in the fuel and cutting power to the engines

Crash no.1: The crash of a British Airways Boeing 777 on landing in London Heathrow was caused by ice crystals forming in the fuel and cutting power to the engines

Crash no.2: The plane slammed into the tarmac before the runway touchdown zone. The engines and the tail fin broke away from the main wreckage

Crash no.2: The plane slammed into the tarmac before the runway touchdown zone. The engines and the tail fin broke away from the main wreckage

This is the third hull loss for a Boeing 777, introduced in 1994.

British Airways Flight 038 from Beijing lost power as it approached the London Heathrow airport on January 17 2008.

Eighteen of those on board needed treatment for minor injuries. Many were hurt as they came out of the plane on its emergency slides.

There were no fatalities but 47 people sustained injuries; one serious.

Intact: An Asiana Airlines Boeing 777 is seen on the runway at San Francisco International Airport after crash landing

Intact: An Asiana Airlines Boeing 777 is seen on the runway at San Francisco International Airport after crash landing

No casualties: In 2008 the BA plane on a flight from China crash-landed short of the runway at London's Heathrow Airport. All the passengers escaped with just a few injuries

No casualties: In 2008 the BA plane on a flight from China crash-landed short of the runway at London's Heathrow Airport. All the passengers escaped with just a few injuries

Everyone survived in London: Fire engines smothered the Boeing 777 in foam after it landed with its wings extensively damaged and its undercarriage wrecked

Everyone survived in London: Fire engines smothered the Boeing 777 in foam after it landed with its wings extensively damaged and its undercarriage wrecked

The 150-tonne aircraft was the first Boeing 777-200ER to be written off in the model's history.

The Boeing 777's engines did not produce the necessary thrust to reach the front of the runway as it came into land.

The plane struck the ground and came to a halt a few hundred yards later.

After a year-long investigation into the causes of the crash, it was found that both engines were still running when the Boeing 777 came down perilously short of the runway but on far less power than had been demanded by the pilot.

Ice crystals in the fuel were found to the cause of the accident.

Although the fuel itself did not freeze, small quantities of water in the fuel did freeze.

Ice adhered to the inside of the fuel lines where they run through the struts attaching the engines to the wings.

This accumulation of ice had no effect on the flight until the final stages of the approach into Heathrow, when increased fuel flow and higher temperatures suddenly released it back into the fuel.

This formed a slush of soft ice which flowed forward where it froze once again, causing a restriction in the flow of fuel to the engines.

The plane's captain Peter Burkill and co-pilot John Coward were hailed as heroes for averting a major disaster.

Britain's Air Accident Investigation Branch said ice blocking the fuel lines that power the engines was the cause of the BA plane losing power.

No obvious cause: It's not immediately clear what made Flight 214 from Seoul crash on landing at San Francisco airport in perfect flying conditions, but there is no shortage of theories

No obvious cause: It's not immediately clear what made Flight 214 from Seoul crash on landing at San Francisco airport in perfect flying conditions, but there is no shortage of theories

Resting place: The plane came to a halt on the grass off the main runway. Incredibly, the fuselage of the aircraft remained intact throughout impact

Resting place: The plane came to a halt on the grass off the main runway. Incredibly, the fuselage of the aircraft remained intact throughout impact

Third time unlucky: This is the third hull loss of a Boeing 777 aircraft since the plane was brought into service in 1995

Third time unlucky: This is the third hull loss of a Boeing 777 aircraft since the plane was brought into service in 1995

In this afternoon's crash at San Francisco Airport it appears the aircraft also did not have the thrust required to meet the threshold of the runway with the tail of the plane striking the tarmac before the wheels touched down.

The impact saw the tail ripped clean off the aircraft's fuselage.

However, the fact that debris exists at the runway's edge, at the perimeter of the tarmac and also in San Francisco Bay ahead of the runways' 'touchdown zone' also suggests the crew were for some reason unable to summon the power they required to make the landing safely.

In any event, whatever the cause, given the proximity of the airport to San Francisco Bay, the crash could have been far worse had the plane crash landed any sooner.

Source: http://www.dailymail.co.uk/news/article-2357585/Crash-landing-San-Francisco-mirrors-Boeing-777-crash-London-Heathrow-years-ago.html?ITO=1490&ns_mchannel=rss&ns_campaign=1490

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Friday, May 10, 2013

1969 Hendrix telegram: Can Paul come to play?

(AP) ? Miles and Jimi. Jimi and Miles. Fans of the late trumpet and guitar masters have long known that Miles Davis and Jimi Hendrix had been making plans to record together in the year before Hendrix's sudden death in 1970.

But less attention has been paid to the bass player they were trying to recruit: Paul McCartney, who was busy with another band at the time.

This tantalizing detail about the super group that never was ? jazz standout Tony Williams would have been on drums ? is contained in an oft-overlooked telegram that Hendrix sent to McCartney at The Beatles' Apple Records in London on Oct. 21, 1969.

"We are recording and LP together this weekend," it says, complete with a typographical error. "How about coming in to play bass stop call Alan Douglas 212-5812212. Peace Jimi Hendrix Miles Davis Tony Williams."

The telegram, advising McCartney to contact producer Douglas if he could make the session, has been part of the Hard Rock Cafe memorabilia collection since it was purchased at auction in 1995. Still it has only generated attention in recent months with the successful release of "People, Hell & Angels," expected to be the last CD of Hendrix's studio recordings.

"It's not something you hear about a lot," Hard Rock historian Jeff Nolan said of the telegram, now displayed at the restaurant in Prague. "Major Hendrix connoisseurs are aware of it. It would have been one of the most insane supergroups. These four cats certainly reinvented their instruments and the way they're perceived."

French promoter and Hendrix fanatic Yazid Manou, who has researched the telegram, says it offers a glimpse of what might have been.

"It's amazing because of the names of the people," he said. "Of course that didn't happen, but the telegram brings us something to dream about. This is a document, proof that they had an idea to do an album."

The telegram raises more questions than it answers. It's not clear if McCartney was even aware of the unusual, apparently impromptu invitation to rush from his London base to New York for the planned session.

Beatle aide Peter Brown replied on McCartney's behalf, telling Hendrix the following day that McCartney was on vacation and not expected back for another two weeks.

The invitation came at an extremely awkward moment for the Beatles' bassist. It was sent the same day a prominent New York City radio station gave wide exposure to a rumor that McCartney had died in a car crash and been replaced by a lookalike. The bizarre story, supposedly supported by hints on Beatles records and album covers, briefly gained worldwide credibility. Its dark nature apparently prompted the exasperated McCartney to retreat with his family to their farm in Scotland.

It also came at a time when the Beatles were falling apart due to business and artistic conflicts that likely would have been exacerbated by McCartney appearing on a record with Hendrix and Davis. McCartney was also still bound by a songwriting partnership with John Lennon that might have further complicated the release of any McCartney-Hendrix-Davis compositions.

And then there is the question of what the proposed group would have sounded like. Davis was moving away from his jazz roots toward a fusion-based sound. He said in his autobiography that by 1968 he was listening primarily to James Brown, Sly and the Family Stone and, particularly, Hendrix ? musicians joined by a love of syncopated funk not found on Beatles' tracks.

It is not clear either how McCartney's melodic, subtle bass playing would have made its presence felt in a band that included Hendrix' guitar and Davis' trumpet.

"At first, though, it sounds really weird and off the wall. But on second thought it makes perfect, Hendrix-type sense to chuck in someone who's a great musician but comes from a different tradition," said Hendrix biographer Charles Shaar Murray. "I regret this never actually took place. ... it would have been magnificent."

McCartney is the only one of the four musicians who is still alive. His spokesman, Stuart Bell, said the former Beatle is too busy on his world tour to comb his memory for his thoughts about a telegram sent more than four decades ago.

In his autobiography, Davis said he and Hendrix occasionally jammed together at his apartment in New York City and tried to get into the studio to record but were hampered by financial matters and by their busy schedules. Murray and others maintain that Davis wanted $50,000 up front to attend the session.

The Juilliard-trained trumpeter Davis described Hendrix, who learned his chops backing up the Isley Brothers and others, as a self-taught "natural musician" who could not read music but was able to pick up complicated pieces in the blink of an eye.

Davis says in the book that he and arranger Gil Evans were in Europe planning to record with Hendrix at the time of his death in London.

"What I didn't understand is why nobody told him not to mix alcohol and sleeping pills," Davis wrote.

Hendrix's death dashed their plans to record together, with or without McCartney. Eddie Kramer, the engineer who produced most of Hendrix's music, said there will always be speculation about what might have been.

"I think it would have been phenomenal," Kramer said. "Lord knows where it may have gone; those huge egos in the studio at the same time! I would have loved to have done that one. But it was not to be."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-05-10-Britain-Hendrix-McCartney-Davis/id-8c103913dd994be38b4365a81c502a37

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China's Efforts To Rapidly Build Its 4G Network Is A Boon For Struggling Telecom Gear Makers

Image (1) chinaflag.jpg for post 161568The Chinese government will reportedly begin issuing 4G licenses (link via Google Translate) by the end of this year or early 2014 at the latest, following news that China Mobile is set to take construction bids for its 4G network as soon as this month. The country's efforts to build out its TD-LTE network as quickly as possible is a potentially lucrative opportunity for telecom equipment makers, which have been hurt by the sluggish global economy.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/LAvQE1-kofg/

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Thursday, May 9, 2013

96% War Witch

All Critics (47) | Top Critics (16) | Fresh (45) | Rotten (2)

Canadian writer-director Kim Nguyen spent nearly a decade researching this docudrama about child soldiers in Africa, and the film feels as authoritative as a first-hand account.

A haunting take on unspeakably grim subject matter, shot on location in the Democratic Republic of Congo.

A powerful and upsetting portrait of a young girl compelled into unimaginably horrific circumstances.

Nguyen, astonishingly, manages to wring something vaguely like a happy ending from this tragic story.

War Witch is most effective not when we are looking in on Komona but when we are inside her head.

The powerful things we expect from "War Witch" are as advertised, but what we don't expect is even better.

... driven by a remarkably natural, unaffected performance by Mwanza. And Nguyen, despite relying a little too heavily on the initial voice-over for exposition, is a confident and sensitive intelligence behind the camera.

You're likely to ponder its images, its insights into a very foreign (for most of us) location and the tragic situation of Komona (and others like her) for a long time to come.

Is it accurate depiction of Africa's child soldiers? I don't know, thank God. But it feels authentic to its very core, and that makes it as hard to forget as it is to ignore.

Brutal without turning exploitative, the result is harrowing and heartbreaking.

Nguyen creates a mesmerizing tone through his camerawork, editing, sound and the infusion of African folk imagery and ritual, but it's Mwanza's performance as Komona that makes "War Witch" feel so miraculous.

Nguyen reportedly worked on "War Witch" for a decade, and it shows in both the immediacy and authenticity of his tale, and the meticulous craft with which it's told.

Made with extremely clear-eyed restraint from harangues, sentiment, message-mongering, or anything else that would cheapen its central character's suffering and fight.

War Witch features a standout performance by Rachel Mwanza, but the supernatural visions don't really suit the film's tone and mood.

Nguyen's compassion and commitment to the issue is admirable, and at its best, War Witch is devastating.

War Witch is remarkable for the fact that it never strays into sentimentality or sensationalism.

...a love story between youngsters who are forced to become adults all too early in their lives.

This is a straight ahead essay on warfare at its worst and the survival of the human spirit at its best.

An astonishing drama set in Africa that vividly depicts the courage and resiliency of a 12-year-old girl whose spiritual gifts enable her to survive.

It is astonishing that film that contains such violence can have such a serene tone. The source of the serenity is the measured, calm narration by Komona (voice of Diane Umawahoro) that is the telling of her story to her unborn child

An exquisitely made film in direct contrast to the ugliness of its subject matter

No quotes approved yet for War Witch. Logged in users can submit quotes.

Source: http://www.rottentomatoes.com/m/war_witch/

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WebMD CEO Redmond leaving; company reports narrower loss

By Pallavi Ail and Adithya Venkatesan

(Reuters) - WebMD Health Corp said Chief Executive Cavan Redmond will be leaving the health information provider, less than a year after the former Pfizer Inc executive was appointed to turn around the company's fortunes.

Shares of the company, which reported a smaller first-quarter loss, were up about 16 percent at $29.50 in after-hours trading. They closed at $25.51 on the Nasdaq on Tuesday.

The company said its senior vice president of strategic and corporate development, David Schlanger, will serve as interim CEO.

WebMD's earnings have been hit as consumers use its websites for specific information only without surfing the other content on the site.

"One of the areas of investment is in the areas of personalization to increase user frequency and how much time they spend on the site when they are there," Schlanger said to Reuters.

WebMD, which operates medical websites providing health and disease related information, has struggled with a fall in advertising revenue with pharmaceutical companies slashing marketing budgets as several blockbuster drugs go off patent.

WebMD also said Anthony Vuolo will be replaced as chief financial officer by Peter Anevski, currently a senior vice-president of finance.

"We do not believe this management change will adversely affect our recent momentum. Results that we issued today along with improved outlook for the balance of the year are a result of the collective efforts of our senior leadership team," WebMD Chairman Martin Wygod said on a conference call with analysts.

UPBEAT OUTLOOK, NEW IDEAS

WebMD expects full-year revenue of $450 million to $470 million, ahead of analysts' expectations of $444.6 million, according to Thomson Reuters I/B/E/S.

The company said it is developing a new channel called the healthcare reform center which will be launched to coincide with the next implementation phase of the Affordable Care Act in the fall.

"We believe that this channel will become a valuable resource for the tens of millions of consumers who will be responsible for choosing a health plan for the first time and will need to understand the impact of the Affordable Care Act (ACA) to themselves and their families," Schlanger said.

Schlanger told Reuters that the channel will be free and open to all users and its purpose will be to provide consumers with content and tools to help in understanding the ACA and make key decisions in choosing their health plan.

The company said the changes in Google's search algorithms increased the traffic to its flagship site, WebMD.com.

Public portal advertising and sponsorship which makes up most of its revenue stream rose 6 percent to $93 million, while overall revenue rose 5 percent to $112.8 million in the first quarter.

Schlanger said about 34 percent of the company's page views were delivered to U.S. mobile devices during the quarter.

"We have been able to sustain our overall traffic growth in an environment where PC traffic has been declining across the web," Schlanger said.

WebMD's net loss narrowed by about 80 percent to $1.5 million, or 3 cents per share, from $7.8 million, or 14 cents per share, a year earlier.

Analysts on average were expecting a loss of 15 cents per share on revenue of $106.6 million.

(Reporting By Pallavi Ail and Adithya Venkatesan in Bangalore; Editing by Anthony Kurian, Roshni Menon and Carol Bishopric)

Source: http://news.yahoo.com/webmd-ceo-redmond-leaving-company-reports-narrower-loss-001636052.html

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Wednesday, May 8, 2013

Benghazi vs. Watergate: Which Was Worse? Part 1 (Powerlineblog)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, RSS and RSS Feed via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/304232594?client_source=feed&format=rss

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Another 'trophy' for the chemistry cabinet

Another 'trophy' for the chemistry cabinet [ Back to EurekAlert! ] Public release date: 7-May-2013
[ | E-mail | Share Share ]

Contact: Lindsay Brooke
lindsay.brooke@nottingham.ac.uk
44-011-595-15751
University of Nottingham

The search for cleaner, low temperature nuclear fuels has produced a shock result for a team of experts at The University of Nottingham.

First they created a stable version of a 'trophy molecule' that has eluded scientists for decades. Now they have discovered that the bonding within this molecule is far different than expected. Remarkably their findings have shown that it behaves in much the same way as its counterparts in the well-known transitional metals such as chromium, molybdenum and tungsten.

The research, done by PhD student David King, which could help in the extraction and separation of the two to three per cent of highly radioactive material in nuclear waste, was led by Professor Stephen Liddle in the School of Chemistry, and has been published in the prestigious academic journal Nature Chemistry.

Professor Liddle said: "The major motivation for doing the first piece of research was to understand the nature of the chemical bonding of uranium. Now we have extended the series to enable meaningful comparisons the 'shock' is that whereas the bonding would be expected to be very different to commonly known and well understood transition metal analogues the bonding is in fact very similar. This is a real surprise and could have an effect on nuclear clean up because differences in chemical bonding are exploited in the separation processes.

Building on previous advances

Working with experts in the Photon Science Institute at The University of Manchester, their latest discovery builds on their previous advances in this area of chemistry, published in the academic journal Science last year.

With funding from the Royal Society, European Research Council, and Engineering and Physical Sciences Research Council the team first established the method to make the 'title molecule'. For the first time they prepared a terminal uranium nitride compound which was stable at room temperature and could be stored in jars in crystallized or powder form.

Previous attempts to do this required temperatures as low as -268 C roughly the equivalent temperature of interstellar space therefore these compounds have, until now, been difficult to work with and manipulate, requiring specialist equipment and techniques.

Exploiting the bonding process

Professor Liddle said: "What the nuclear industry wants to do is minimise the volume of waste by extracting the radioactive elements from spent fuel. This relies on exploiting differences in the bonding, but in some circumstances it may be surprisingly similar and this is going to be important in the amelioration of nuclear waste clean-up and devising new atom-efficient catalytic cycles."

The way atoms behave in uranium bonding is still unclear and there is much debate and great interest in respect to the nature of uranium nitride materials because they have the potential to offer a viable alternative to the mixed oxide nuclear fuels currently used in reactors. Nitrides exhibit superior high densities, melting points and thermal conductivities and the process this team of researchers has developed could offer a cleaner, low temperature route reducing the amount of impurities which are difficult to remove from the waste produced by current fuels.

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Another 'trophy' for the chemistry cabinet [ Back to EurekAlert! ] Public release date: 7-May-2013
[ | E-mail | Share Share ]

Contact: Lindsay Brooke
lindsay.brooke@nottingham.ac.uk
44-011-595-15751
University of Nottingham

The search for cleaner, low temperature nuclear fuels has produced a shock result for a team of experts at The University of Nottingham.

First they created a stable version of a 'trophy molecule' that has eluded scientists for decades. Now they have discovered that the bonding within this molecule is far different than expected. Remarkably their findings have shown that it behaves in much the same way as its counterparts in the well-known transitional metals such as chromium, molybdenum and tungsten.

The research, done by PhD student David King, which could help in the extraction and separation of the two to three per cent of highly radioactive material in nuclear waste, was led by Professor Stephen Liddle in the School of Chemistry, and has been published in the prestigious academic journal Nature Chemistry.

Professor Liddle said: "The major motivation for doing the first piece of research was to understand the nature of the chemical bonding of uranium. Now we have extended the series to enable meaningful comparisons the 'shock' is that whereas the bonding would be expected to be very different to commonly known and well understood transition metal analogues the bonding is in fact very similar. This is a real surprise and could have an effect on nuclear clean up because differences in chemical bonding are exploited in the separation processes.

Building on previous advances

Working with experts in the Photon Science Institute at The University of Manchester, their latest discovery builds on their previous advances in this area of chemistry, published in the academic journal Science last year.

With funding from the Royal Society, European Research Council, and Engineering and Physical Sciences Research Council the team first established the method to make the 'title molecule'. For the first time they prepared a terminal uranium nitride compound which was stable at room temperature and could be stored in jars in crystallized or powder form.

Previous attempts to do this required temperatures as low as -268 C roughly the equivalent temperature of interstellar space therefore these compounds have, until now, been difficult to work with and manipulate, requiring specialist equipment and techniques.

Exploiting the bonding process

Professor Liddle said: "What the nuclear industry wants to do is minimise the volume of waste by extracting the radioactive elements from spent fuel. This relies on exploiting differences in the bonding, but in some circumstances it may be surprisingly similar and this is going to be important in the amelioration of nuclear waste clean-up and devising new atom-efficient catalytic cycles."

The way atoms behave in uranium bonding is still unclear and there is much debate and great interest in respect to the nature of uranium nitride materials because they have the potential to offer a viable alternative to the mixed oxide nuclear fuels currently used in reactors. Nitrides exhibit superior high densities, melting points and thermal conductivities and the process this team of researchers has developed could offer a cleaner, low temperature route reducing the amount of impurities which are difficult to remove from the waste produced by current fuels.

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-05/uon-af050713.php

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Wednesday, March 6, 2013

Key to heart failure: New therapies on horizon

Mar. 5, 2013 ? Some 5.8 million Americans suffer from heart failure, a currently incurable disease. But scientists at Temple University School of Medicine's (TUSM) Center for Translational Medicine have discovered a key biochemical step underlying the condition that could aid the development of new drugs to treat and possibly prevent it.

"Drugs we currently use for heart failure are not very effective," explained lead investigator Walter J. Koch, PhD, Professor and Chairman of the Department of Pharmacology at TUSM, and Director of the Center for Translational Medicine at TUSM. But, he added, "The more we learn about the disease mechanism, the more drug targets we'll find."

That is what Koch and colleagues at Thomas Jefferson University and the University of California, Davis, achieved in their latest study, which appears in the March 5 issue of the online journal PLOS ONE. The report is the first to show that an enzyme called GRK5 (G-protein coupled receptor kinase 5) can gain access to a heart cell's nucleus -- its command center, where control of its genes is maintained -- by way of a transport mechanism involving calcium and a protein known as calmodulin. Once calcium and calmodulin deliver GRK5 to the nucleus, the enzyme usurps control over specific genes, ultimately causing hypertrophy, in which heart cells grow larger in size. Hypertrophy is a biological hallmark of heart failure.

GRK5 had previously been identified as a key player in maladaptive cardiac hypertrophy, which is the end stage of heart failure, when the heart muscle becomes enlarged and unable to pump enough blood to keep vital organs functioning. While GRK5's ability to get inside the nucleus was known, Koch and colleagues worked to fill in the missing links in its transport mechanism. Those links, they hope, will not only allow them to better understand GRK5's role in causing heart cells to increase in size but also find ways to block that process to more effectively treat heart failure.

The GRK5 enzyme is a unique member of the GRK family, owing to its presence in the nucleus. Its journey begins at the cell membrane, where signals received by a molecule at the cell surface known as a Gq-coupled receptor prompt "escorts" -- one of which is calmodulin, as the researchers discovered -- to attach to GRK5 and guide it to the nucleus.

The team found that GRK5's transport requires calmodulin after examining different places on the enzyme where various escort molecules attach. They then introduced mutations that altered the attachment sites. Only when calmodulin-binding residues on GRK5 were mutated was the enzyme prevented from reaching the nucleus. Those mutations led to dramatic decreases in nuclear GRK5 levels and corresponding declines in the activity of genes known to drive cardiac hypertrophy. Calmodulin's ability to bind to GRK5 is in turn dependent on calcium. The same results were obtained both in vitro, using human heart muscle cells cultivated under laboratory conditions, and in vivo, in mice.

The team's research also marks a breakthrough in scientists' understanding of the role of neurohormones in hypertrophy. Released by specialized neurons into the bloodstream, neurohormones have long been cited as a cause of heart cell enlargement.

"One of the novel findings to fall out of this paper is that not all hypertrophic signals from neurohormones are the same," Koch explained. "That's something to keep in mind as we move forward."

The next step, according to Koch, is to test the ability of different agents to keep GRK5 out of the nucleus. "We are now discussing a trial on inhibition of another cardiac GRK, GRK2," he said. He cautioned, however, that trials in patients with GRK5 inhibition are years away. First, agents capable of blocking GRK5 transport must be identified and tested in animals.

The work is an important advance for Temple's Center for Translational Medicine. GRK5 enters the pipeline of novel drug targets under investigation by the Center's scientists and clinicians, who share the common goal of coordinating clinical practice and basic research to speed the delivery of new therapies to patients.

"It's another entry into larger, pre-clinical animal studies," Koch said. "Something new to start down the path of translational medicine."

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Story Source:

The above story is reprinted from materials provided by Temple University Health System, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Jessica I. Gold, Jeffrey S. Martini, Jonathan Hullmann, Erhe Gao, J. Kurt Chuprun, Linda Lee, Douglas G. Tilley, Joseph E. Rabinowitz, Julie Bossuyt, Donald M. Bers, Walter J. Koch. Nuclear Translocation of Cardiac G Protein-Coupled Receptor Kinase 5 Downstream of Select Gq-Activating Hypertrophic Ligands Is a Calmodulin-Dependent Process. PLoS ONE, 2013; 8 (3): e57324 DOI: 10.1371/journal.pone.0057324

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/ro7vXNjnLys/130305174655.htm

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Friday, March 1, 2013

Senator Seeks More Data Rights for Online Consumers

Before his planned retirement from Congress at the end of next year, Senator John D. Rockefeller IV, the West Virginia Democrat, intends to give American consumers more meaningful control over personal data collected about them online.

To that end, Mr. Rockefeller on Thursday introduced a bill called the ?Do-Not-Track Online Act of 2013.?

The bill would require the Federal Trade Commission to establish standardized mechanisms for people to use their Internet browsers to tell Web sites, advertising networks, data brokers and other online entities whether or not they were willing to submit to data-mining.

The bill would also require the F.T.C. to develop rules to prohibit online services from amassing personal details about users who had opted out of such tracking.

Mr. Rockefeller proposed the same bill two years ago. But he did not push it in the Senate at the time because industry groups had pledged to voluntarily develop systems to honor the browser-based don?t-track-me flags. Last year, however, negotiations between industry groups and consumer advocates over how to execute these mechanisms essentially broke down and have since made little progress.

The new Rockefeller bill indicates that the senator believes the industry has not acted in good faith.

?The privacy of Americans is increasingly under assault as more and more of their daily lives are conducted online,? Mr. Rockefeller, the chairman of the Senate Committee on Commerce, Science and Transportation, wrote on Thursday in an e-mail sent to a reporter. ?Industry made a public pledge to develop do-not-track standards that will truly protect consumer privacy ? and it has failed to live up to that commitment. They have dragged their feet long enough.?

Industry representatives said that legislation was unnecessary because advertising networks and data brokers several years ago voluntarily introduced their own opt-out program for consumers, called Your AdChoices. Unlike the Do Not Track signals which would allow users to make a one-time decision about all online tracking from their own browsers, the industry program requires people to go to a site and individually select the companies, among several hundred, from whom they prefer not to receive marketing offers based on data-mining.

Stuart Ingis, a lawyer for the Digital Advertising Alliance, an industry consortium, said the program, which involves consumers installing individual cookies on their browsers, demonstrates that users already have choices about data collection.

?It?s a lot easier to use a system that is already built and works,? Mr. Ingis said.

Over the last few years, the number of companies that collect information about the reading habits, health concerns, financial capacity, search queries, purchasing patterns and other activities of online consumers has skyrocketed. Industry representatives argue that this benefits people because it enables companies to show them relevant ads, and that the ads themselves finance online sites and services that are free to consumers. Moreover, they say, the data collection is ?anonymous? because online services typically use numerical customer codes, not real names or e-mail addresses, to track the behavior of individuals.

But consumer advocates warn that such profiling systems, which can collect thousands of details on nearly every adult in the United States, can be used to segment some people for preferential offers while relegating others to inferior treatment. Despite industry claims that online tracking is anonymous, a few computer scientists have reported that sites often leak information that can identify individuals, including names, addresses and other details, to third parties.

?Nowadays, there is an incredible proliferation of tracking,? said Dan Auerbach, a staff technologist at the Electronic Frontier Foundation, a digital rights group in San Francisco. ?Data brokers, companies that you never heard of, are collecting massive dossiers about you as you browse around the Web and, right now, there are no limitations on the collection or use of those dossiers.?

To give people greater control over their own surveillance online, the Federal Trade Commission in a report on consumer privacy last March urged industry groups to adopt Do Not Track mechanisms by the end of 2012. In fact, the major browsers ? Firefox from Mozilla, Google?s Chrome, and the more recent iterations of Internet Explorer ? already offer the don?t-track-me buttons. When these options are turned on, they send out signals to sites, and third parties like ad networks operating on those sites, that certain users do not want to have their information collected.

But industry groups and consumer advocates have been at odds for more than a year over how ?Do Not Track? mechanisms should be presented to users and how online services should respond to the signals. In the absence of legislation or industry consensus, companies are free to ignore those user preferences.

Some browsers have responded to this standstill by taking matters into their own hands and blocking third-party tracking cookies, as my colleague Somini Sengupta reported this week.

But Mr. Rockefeller?s bill indicates that legislative action could pre-empt voluntary industry measures.

?This is a signal that Senator Rockefeller is serious about getting Do Not Track done,? said David C. Vladeck, a professor at Georgetown Law. Until last month, Mr. Vladeck served as director of the bureau of consumer protection at the F.T.C. ?I think industry writ large ? browser companies, advertising networks, data brokers ? are going to understand that he is serious about getting across the finish line.?

Source: http://bits.blogs.nytimes.com/2013/02/28/senator-seeks-more-data-rights-for-online-consumers/

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